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ForumsMASH / Liver DiseaseALT normalization rates on GLP-1 — looking for input Page 3

ALT normalization rates on GLP-1 — looking for input

bbq_ray_KC Mon, Apr 27, 2026 at 9:54 AM 24 replies 793 viewsPage 3 of 5
DadBodDave
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Apr 29, 2026 at 9:22 AM#11
PharmacoVig_BOS said:
Liver ultrasound comparison for liver and MASH: my hepatologist ordered serial ultrasounds to track NAFLD regression.

Thank you for spelling out the reasoning rather than just the conclusion. Printing the relevant bit and taking it with me.

2 0laura_annarbor, JenMemphis
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lisa_labSD
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Apr 29, 2026 at 12:22 PM#12

Adding the clinical framing, because it changes how the question reads. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

3 1maya_sedona, stefan_berlin, Dr.EM_Chicago
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KevinCompounds
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Apr 29, 2026 at 3:22 PM#13
TrialTracker_MD said:
Liver enzyme update related to liver and MASH: I had mildly elevated ALT/AST at baseline (likely NAFLD).

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

4 2MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 1 other
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raj_cambridge
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Apr 29, 2026 at 6:22 PM#14

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Apr 29, 2026 at 7:22 PM
5 3PharmHunterJen, TomTeleRx, DoseLogDan and 2 others
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mike_mod
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Apr 29, 2026 at 9:22 PM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Report rather than reply if it drifts again.

6 4PurityPaulOR, MaxMetOK, MounjBrad and 3 others
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