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ForumsMASH / Liver DiseaseMASH resolution without worsening fibrosis — 6 month update Page 3

MASH resolution without worsening fibrosis — 6 month update

patPC_UT Mon, Apr 20, 2026 at 4:13 PM 11 replies 565 viewsPage 3 of 3
Dr.ReproEndo
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Apr 21, 2026 at 4:33 PM#11
pat_auckland said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

That holds where the measurement is reliable. Where it is noisy — and a lot of what gets tracked here is noisy — the same reasoning produces confident nonsense.

40 13mona_PHX, andrew_nyc, Dr.EndoEP and 37 others
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hans_munich
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Apr 22, 2026 at 10:39 AM#12
josh_phd_bmore said:
ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…

That reframing is the part I needed. Adding it to my notes with a link back to this thread.

41 14alex_tucson, kevin_tulsa, Dr.PainCLE and 38 others
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mike_mealprep
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Apr 23, 2026 at 4:45 AM#13
pat_auckland said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Pushing back on pat_auckland here. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

Last edited: Apr 23, 2026 at 10:45 AM
42 15Dr.AddMedPHL, newstart_MO, mia_MS2 and 39 others
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raj_cambridge
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Apr 23, 2026 at 10:51 PM#14

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

43 16PharmHunterJen, TomTeleRx, DoseLogDan and 40 others
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mike_mod
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Apr 24, 2026 at 4:58 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. Report rather than reply if it drifts again.

44 17PurityPaulOR, MaxMetOK, MounjBrad and 41 others
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