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ForumsSemaglutide (Ozempic / Wegovy)Sema fatigue at month 6 — September 2026

Sema fatigue at month 6 — September 2026

SleepDoc_PDX Sat, Sep 27, 2025 at 2:14 AM 4 replies 1,114 viewsPage 1 of 1
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SleepDoc_PDX
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Sep 27, 2025 at 2:14 AM#1

I am tired in a way that does not respond to sleep, which is different from the tiredness I had before any of this started.

Worth checking before concluding it is the drug: ferritin, B12, TSH, and total intake for three honest days. Two of those four explain most cases.

The narrow version of the question is whether the fatigue is a direct drug effect or simply the caloric deficit, because the answer changes what you do about it.

Happy to be told the question itself is wrong.

18 13pete_nash, hank_denver, carlos_SATX and 15 others
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BariatricNurseD
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Sep 27, 2025 at 2:30 AM#2

This one has a reasonably settled answer, so here it is. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Last edited: Sep 27, 2025 at 7:30 AM
17 12roxy_nash, tony_orlando, Dr.NephBHM_UK and 14 others
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matt_MKE
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Sep 27, 2025 at 2:46 AM#3
BariatricNurseD said:
The mechanism and the magnitude are separate questions.

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

16 11GraceAZ_72, carl_compliance, DanielChem_CHI and 13 others
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MounjBrad
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Sep 27, 2025 at 3:02 AM#4
SleepDoc_PDX said:
I am tired in a way that does not respond to sleep, which is different from the tiredness I had before any of this started.

Second this. Posting only so the count is not one.

15 10pam_columbus, nick_SD_fit, ben_calgary and 12 others
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Dr.BariatricHTX
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Sep 27, 2025 at 4:29 AM#5

Adding the clinical framing, because it changes how the question reads. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

I would rather be corrected than agreed with, if it comes to it.

14 9maya_sedona, stefan_berlin, Dr.EM_Chicago and 11 others
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