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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOther Peptides & Research CompoundsAre any of these other peptides actually backed by science — May 2025 Page 3

Are any of these other peptides actually backed by science — May 2025

maria_elpaso Wed, Apr 16, 2025 at 2:33 AM 16 replies 1,686 viewsPage 3 of 4
carlos_SATX
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Apr 16, 2025 at 7:06 PM#11
Dr.NephBHM_UK said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

Last edited: Apr 16, 2025 at 9:06 PM
40 13james_edin, FranDenver, Dr.BariatricHTX and 37 others
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Dr.PathRoch
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Rochester, MN
Apr 16, 2025 at 9:08 PM#12

From the other side of the consultation, briefly. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Last edited: Apr 17, 2025 at 3:08 AM
41 14InsuranceTom, WendyG_ATL, SaraMom3 and 38 others
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TrialNerd_Beth
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Apr 16, 2025 at 11:10 PM#13
Dr.LeslieOBGYN said:
Amycretin (AMY/GLP-1 dual agonist) emerging data relevant to the pharmacology: Phase 1 showed -13.1% body weight at only 12 weeks, the fastest…

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

Last edited: Apr 17, 2025 at 3:10 AM
42 15TomTeleRx, DoseLogDan, SleepFixSam and 39 others
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Dr.AddMedPHL
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Mar 2024
Philadelphia, PA
Apr 17, 2025 at 1:12 AM#14

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

43 16TomFromTexas, mike.trainer_LA, sarah_nash92 and 40 others
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mike_mod
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Apr 17, 2025 at 3:14 AM#15

Moderator note: a couple of off-topic posts removed. Thread quality here is what the rules are for. Keep it up.

Last edited: Apr 17, 2025 at 5:14 AM
44 17PurityPaulOR, MaxMetOK, MounjBrad and 41 others
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