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ForumsMASH / Liver DiseaseQuit drinking AND started sema - liver is thanking me — March 2026 Page 2

Quit drinking AND started sema - liver is thanking me — March 2026

chris_chi24 Mon, Feb 2, 2026 at 7:39 AM 21 replies 1,128 viewsPage 2 of 5
BariatricNurseD
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Feb 2, 2026 at 8:01 PM#6
PurityPaulOR said:
The liver data is among the strongest non-weight findings in the class.

I read this differently from PurityPaulOR, on substance rather than tone. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Last edited: Feb 3, 2026 at 1:01 AM
39 9tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 36 others
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TirzTom
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Feb 3, 2026 at 12:54 AM#7

One concrete data point for the thread. With resmetirom now available for MASH, combination approaches are being explored, so the standard of care in this area is moving faster than most threads assume.

Happy to go further on any of that.

Last edited: Feb 3, 2026 at 4:54 AM
38 8tom_AK, josh_phd_bmore, roxy_nash and 35 others
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Dr.KarenChen
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Feb 3, 2026 at 5:47 AM#8
BariatricNurseD said:
This treats a plausible mechanism as a demonstrated one.

There is a second half to this that has not been said yet. The distinction that resolves most of these threads is between what is true on average and what is true for one person. Both are real; they answer different questions and get quoted as if they were the same one.

37 7TomFromTexas, mike.trainer_LA, sarah_nash92 and 34 others
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oliver_london
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Feb 3, 2026 at 10:40 AM#9

A narrower follow-up, since the general answer is now clear:

Whether normalised enzymes tell you anything about fibrosis, and what the right follow-up measurement is?

36 6jason_paloalto, Dr.LeslieOBGYN, MikeNYC_runner and 33 others
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chris_chi24
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Feb 4, 2026 at 10:08 AM#10

Reporting back.

Closing the loop. The answer turned out to depend on the detail I had left out of the opening post, which is a lesson about how to ask rather than about the subject.

40 13SleepFixSam, PurityPaulOR, MaxMetOK and 37 others
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