PharmHunterJen said:There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.
This is my experience too, for whatever a second data point is worth. I had assumed I was the exception until I read this.
PeptideChemSF said:If you are going to change something, change one thing and give it long enough to express itself.
That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.
Happy to go further on any of that.
PeptideChemSF said:If you are going to change something, change one thing and give it long enough to express itself.
Thank you — that is the clearest version of this I have read, and I have read a lot of them. Taking it to my next appointment.
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Shop Reference StandardsFrom the other side of the consultation, briefly. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.