FDA_TrackerJim said:

The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

FDA_TrackerJim said:

The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Agreed, and one caution: a single measurement is not a measurement. Anything that moves day to day needs a trend before it means anything at all.

FDA_TrackerJim said:

The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Genuinely useful, thank you. I had the facts and not the framework.

Clinical perspective, offered as context rather than as advice. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

DeniseRN_TPA said:

There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Can confirm. Same sequence, different timescale.