Dr.EM_Chicago said:Mostly the deficit, and the useful part of that answer is that it is testable.
Agreed, though "tolerable" needs defining. A dose you tolerate by eating almost nothing is not tolerated, it is being paid for somewhere else — usually in lean mass, sometimes in adherence three months later.
sophie_paris said:The mechanism that matters here is not stomach emptying, it is central.
Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.
Dr.EM_Chicago said:Mostly the deficit, and the useful part of that answer is that it is testable.
This is where I part company with the consensus forming above. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.
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View ResultsOne concrete data point for the thread. Worth checking before concluding it is the drug: ferritin, B12, TSH, and total intake for three honest days. Two of those four explain most cases.