NurseKim_ATL said:

COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis: No HPLC data: If there's no…

My vendor review relevant to certificates of analysis: ordered 6 times from my current compounder. Consistency has been excellent.

Shipping: 3-day with temperature monitor
Packaging: Professional, discreet, proper labeling with lot/batch numbers
Purity: 99.3% average across orders (Janoshik verified)
Customer service: Responsive within 1 hours
Price: $123/month for semaglutide 1.7mg equivalent

TrialTracker_MD said:

Agreed, and mass spec answers a question purity does not: identity.

This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.

NurseKim_ATL said:

COA red flags for certificates of analysis — here's what to look for when reviewing a Certificate of Analysis: No HPLC data: If there's no…

HPLC results interpretation for certificates of analysis: when you get your Janoshik report back, here's what the numbers mean:

• Purity %: Should be >97%. Below 95% is concerning.
• Retention time: Should match reference standard for the peptide
• Related substances: Degradation products should be <2% total
• Single impurity: No individual impurity should exceed 1%

My last batch: 99.5% purity, 0.3% total related substances. Clean chromatogram with single sharp peak at expected retention time. Exactly what you want to see.

PurityPaulOR said:

I have a certificate reporting 99.2% purity and 6.1mg content on a vial sold as 5mg, and I cannot work out whether those two numbers are consistent or…

I tested my certificates of analysis batch through Janoshik — 98.4% purity. That's within acceptable range for compounded peptides. Turnaround was 12 business days.

The test costs ~$121 but gives you actual HPLC chromatography data plus mass spec confirmation. For the peace of mind alone, it's worth every penny. I test every new batch from a new vendor.

Moderator note: the sourcing question belongs in the vendor section and has been split out. Carry on.