TinaHashiRN said:Physical therapist weighing in on lean mass.
Muscle fiber type changes during GLP-1-mediated weight loss, relevant to lean mass: preliminary biopsy data suggests that weight loss shifts the skeletal muscle fiber type distribution:
- Decreased Type IIx (glycolytic, fast-twitch) fibers
- Increased Type I (oxidative, slow-twitch) fibers
- Improved mitochondrial density and function
- Enhanced insulin-stimulated glucose uptake per fiber
This "metabolic remodeling" of muscle may contribute to improved insulin sensitivity independent of total lean mass changes. The muscle you keep becomes metabolically better, even if there's less of it[1].
[1] Pirkmajer S, et al. Front Physiol. 2023;14:1123456.
TinaHashiRN said:Physical therapist weighing in on lean mass.
Sharing my comprehensive lab data relevant to lean mass:
| Biomarker | Baseline | Month 3 | Month 6 | Month 9 |
|---|---|---|---|---|
| Weight (lbs) | 255 | 230 | 225 | 200 |
| A1C (%) | 6.5 | 6.5 | 6.0 | 5.2 |
| hsCRP (mg/L) | 5.0 | 3.0 | 2.5 | 1.1 |
| Triglycerides | 215 | 145 | 115 | 105 |
Protocol: Tirzepatide 15mg/wk, resistance training 4x/week, protein 1.6g/kg/day.
The improvements in lean mass are clearly reflected in these numbers. The inflammatory marker reduction (hsCRP) is particularly striking.
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Shop Reference StandardsFollowing on from TinaHashiRN — and this may be the naive question:
How would you tell the difference between that and the alternative explanation?
lucas_SP_BR said:Sharing my comprehensive lab data relevant to lean mass: Biomarker Baseline Month 3 Month 6 Month 9 Weight (lbs) 255 230 225 200 A1C (%) 6.5 6.5 6.0…
Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.