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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab Results100 lbs lost in 14 months — 12 month update Page 5

100 lbs lost in 14 months — 12 month update

claudia_zurich Mon, Feb 2, 2026 at 9:02 AM 37 replies 1,305 viewsPage 5 of 8
JenPlateau
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Feb 5, 2026 at 3:23 PM#21
GenomicsKate said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Adding the part of the answer the thread has not reached. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

12 10HPLC_Greg, LibrarianMeg, bri_stats and 9 others
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LabKate
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Feb 6, 2026 at 2:35 PM#22

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

13 11laura_annarbor, JenMemphis, pat_auckland and 10 others
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jim_asheville
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Feb 7, 2026 at 1:47 PM#23

Following on from GenomicsKate — and this may be the naive question:

Was that from a primary source or from a summary of one?

14 12NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 11 others
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nick_SD_fit
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Feb 8, 2026 at 12:58 PM#24
LabKate said:
One practical note: write down what you did and when, before you need it.

Pushing back on LabKate here. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Last edited: Feb 8, 2026 at 2:58 PM
15 13PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 12 others
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KevinCompounds
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Feb 9, 2026 at 12:08 PM#25
LabKate said:
One practical note: write down what you did and when, before you need it.

Agreeing with LabKate, and the qualification matters more than the agreement. Yes, and the corollary is less popular: if the reasoning holds, it also holds where it produces an answer we do not like.

Last edited: Feb 9, 2026 at 2:08 PM
16 14NurseAsh_DET, BenResearch_OR, MikeKY_noInsulin and 13 others
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