pete_manc_UK said:

The line between titrate-through and stop is not severity, it is trajectory and what else is present.

I dislike how confidently this board tells people to push through. Incidence figures around 20 to 25% at the higher doses are class-typical, but the trials also had a discontinuation column, and "manageable with protocols" is not the same as manageable for everyone.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

One concrete data point for the thread. If you are comparing against somebody else’s result, check that you are comparing the same measurement taken the same way. Most of the apparent contradictions in these threads dissolve at that step.

julia.endo said:

I dislike how confidently this board tells people to push through.

There is a second half to this that has not been said yet. There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

Correct me if the detail matters more than I have assumed.

A narrower follow-up, since the general answer is now clear:

What distinguishes the nausea you can titrate through from the nausea that means stop?

OP back with an update, since a thread like this is useless without one.

Update. It was not the dose, it was that I had stopped drinking anything because drinking made me feel full. Fixing that fixed most of it.