Dr.CardioMD said:The mechanism and the magnitude are separate questions.
Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.
MASHdoc_SA said:ATTAIN trial (survodutide) context for liver and MASH: survodutide, a GLP-1/glucagon dual agonist, showed -18.7% body weight at 46 weeks in the Phase…
That reframing is the part I needed. Sending this to two other people who asked me the same thing last week.
Dr.CardioMD said:The mechanism and the magnitude are separate questions.
Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.
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Browse GL BiochemAdding the numbers, since they settle part of this. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.
Moderator note: a couple of off-topic posts removed. Thread quality here is what the rules are for. Keep it up.