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ForumsSide Effects & ManagementGallbladder disease risk — my results so far

Gallbladder disease risk — my results so far

COA_Karl Fri, Jul 11, 2025 at 10:38 PM 27 replies 1,432 viewsPage 1 of 6
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COA_Karl
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Jan 2024
Pennsylvania
Jul 11, 2025 at 10:38 PM#1

Lost weight quickly, developed right-upper-quadrant pain after fatty meals, and ended up having an ultrasound that found what everybody had already guessed.

The question I want answered is how much of the gallbladder signal is the drug and how much is simply the rate of weight loss, because the answer changes what you can do about it.

I have searched first, so if this is covered somewhere point me at it and I will read it.

8 3matt_MKE, Dr.ReproEndo, lucas_SP_BR and 5 others
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JennaRN
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Jul 11, 2025 at 10:46 PM#2
COA_Karl said:
Lost weight quickly, developed right-upper-quadrant pain after fatty meals, and ended up having an ultrasound that found what everybody had already…

Gallbladder ultrasound monitoring on gallbladder risk: given the known gallstone risk with rapid weight loss, my doctor orders gallbladder ultrasound every 6 months:

Baseline: normal, no stones or sludge
Month 6: small amount of biliary sludge, no stones
Month 12: sludge resolved, gallbladder normal

Ursodeoxycholic acid (Ursodiol) 300mg BID was prescribed prophylactically from the start. This reduces gallstone formation during rapid weight loss by ~60% per the available data. Ask your doctor about prophylactic ursodiol if you're losing weight rapidly.

7 2PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 4 others
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Dr.AddMedPHL
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Mar 2024
Philadelphia, PA
Jul 11, 2025 at 10:54 PM#3
JennaRN said:
Gallbladder ultrasound monitoring on gallbladder risk: given the known gallstone risk with rapid weight loss, my doctor orders gallbladder ultrasound…

Gallbladder warning for gallbladder risk: rapid weight loss increases gallstone risk regardless of method. GLP-1 patients have a ~2-3% incidence of gallbladder events in clinical trials.

Symptoms to watch for: pain in upper right abdomen after fatty meals, nausea after eating, pain radiating to right shoulder. I had my gallbladder out at month 6 — it was full of stones. My surgeon said it's very common in significant weight loss patients.

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adam_van
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Nov 2024
Vancouver, CA
Jul 11, 2025 at 11:02 PM#4
COA_Karl said:
Lost weight quickly, developed right-upper-quadrant pain after fatty meals, and ended up having an ultrasound that found what everybody had already…

Mine went the same way, slower.

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rachel_ABQ
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Dec 2024
Albuquerque, NM
Jul 11, 2025 at 11:44 PM#5

From the other side of the consultation, briefly. The useful move here is to separate what is established from what is widely repeated. Those two sets overlap less than the confident tone of most write-ups suggests, and the second set is where nearly all the disagreement on this board comes from.

Last edited: Jul 12, 2025 at 4:44 AM
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