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ForumsCOA & Analytical TestingRed flags on COAs — my results so far Page 2

Red flags on COAs — my results so far

WendyG_ATL Sun, Dec 28, 2025 at 4:49 AM 10 replies 970 viewsPage 2 of 2
Dr.GutHealth
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Dec 28, 2025 at 8:14 AM#6

The figures, for anyone assembling their own picture. The four things to check on any report, in order: does it name your batch, who commissioned it, what method was used, and does it report content as well as purity. A report failing any of those is weak evidence regardless of the percentage on it.

Worth separating that from certificates of analysis, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Dec 28, 2025 at 1:14 PM
44 14VanRx_Mike, steve_okc, dave_SLC and 41 others
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MariaRD
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Dec 28, 2025 at 9:34 AM#7

A narrower follow-up, since the general answer is now clear:

What a vetting checklist should actually contain, as opposed to a list of things that are easy to fake?

43 13anders_CPH, Dr.NutriCornell, pam_stl and 40 others
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Dr.SurgeonPGH
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Dec 28, 2025 at 10:54 AM#8
Dr.GutHealth said:
The four things to check on any report, in order: does it name your batch, who commissioned it, what method was used, and does it report content as…

Adding the part of the answer the thread has not reached. They are not contradictory, they measure different things, and this is the single most common misreading of a certificate. Purity is a relative area measurement: the main peak as a percentage of total peak area in the chromatogram. Content is an absolute mass measurement against a reference standard. A vial can be 99% pure and contain 6.1mg — pure material, overfilled — or 99% pure and contain 3mg, which is pure material and a short fill. Purity tells you what fraction of what is there is the right molecule; content tells you how much of it there is. You need both, and a certificate with only purity is telling you half the story.

42 12PharmHunterJen, TomTeleRx, DoseLogDan and 39 others
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Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

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WendyG_ATL
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Dec 28, 2025 at 12:14 PM#9

Closing the loop on my own question.

Went back through my own correspondence with an earlier supplier and the warning signs were all there in the replies, weeks before the quality changed. I was reading the product and not the behaviour.

41 11AttorneyGrant, DebRD_ATL, KristenIndy and 38 others
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tyler_CSCS
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Dec 28, 2025 at 6:37 PM#10
Dr.SurgeonPGH said:
They are not contradictory, they measure different things, and this is the single most common misreading of a certificate.

Right, and one flattering data point from a group buy is not consistency. Consistency means separate batches, separately commissioned, over months.

Last edited: Dec 28, 2025 at 8:37 PM
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