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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsNot losing weight but my clothes fit different?? Explain — September 2026

Not losing weight but my clothes fit different?? Explain — September 2026

Dr.NephBHM_UK Wed, Mar 5, 2025 at 8:57 PM 8 replies 1,529 viewsPage 1 of 2
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Dr.NephBHM_UK
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Mar 5, 2025 at 8:57 PM#1

Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several times.

The question I want answered is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything.

I would rather have one careful answer than five confident ones.

17 12Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 14 others
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Dr.ObesityMed
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Mar 5, 2025 at 9:03 PM#2
Dr.NephBHM_UK said:
Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Plateau breaking story with a stall: I stalled at 196 lbs for 8 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: adding HIIT cardio 2x/week. Lost 10 lbs in the next 3 weeks. Plateaus are temporary — they always break if you stay consistent.

16 11PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 13 others
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pam_columbus
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Mar 5, 2025 at 9:09 PM#3
Dr.ObesityMed said:
Plateau breaking story with a stall: I stalled at 196 lbs for 8 weeks.

That is correct as far as it goes, and here is where it stops going. Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body. A body 20kg lighter needs meaningfully fewer calories at rest and less to move, so the deficit that produced the first phase is arithmetically smaller now. The options are the honest ones — increase the deficit slightly, increase activity, or accept the new plateau — and escalating the dose is only one of them.

15 10Dr.LipidDallas, alex_tucson, kevin_tulsa and 12 others
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hank_denver
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Mar 5, 2025 at 9:15 PM#4
Dr.NephBHM_UK said:
Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Mine went the same way, slower.

14 9fiona_VT, denise_HTX, raj_cambridge and 11 others
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traveltech_sara
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Mar 5, 2025 at 9:44 PM#5

Adding the clinical framing, because it changes how the question reads. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

13 8BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 10 others
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