Dr.SportsMedIN said:

The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

Agreed, and for anyone with an eating-disorder history this needs a clinician in the loop rather than a forum. The same drug can be therapeutic in binge-eating disorder and actively harmful in a restrictive disorder.

MarkLI_maint said:

Agreed on the target, with the caveat that reference weight and current weight are different numbers.

Saving this. It is the first explanation that did not require me to already understand it. Taking it to my next appointment.

Dr.SportsMedIN said:

The mental-health dimension is under-measured in the trial literature and the reports here are consistent enough to take seriously.

This is where I part company with the consensus forming above. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

The figures, for anyone assembling their own picture. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

That is the short version; the long version is somebody else's post.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source.