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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsHas anyone dealt with crp from 12.4 to 0.8?

Has anyone dealt with crp from 12.4 to 0.8?

FranDenver Tue, Jul 9, 2024 at 7:17 PM 32 replies 2,150 viewsPage 1 of 7
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FranDenver
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Jul 9, 2024 at 7:17 PM#1

Read the primary source rather than the write-up and the two do not agree, so here is what is actually in it.

Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body. A body 20kg lighter needs meaningfully fewer calories at rest and less to move, so the deficit that produced the first phase is arithmetically smaller now. The options are the honest ones — increase the deficit slightly, increase activity, or accept the new plateau — and escalating the dose is only one of them.

Where I think it is weakest: the completion rate deserves as much attention as the headline, because a large effect among those who finished is a different claim from a large effect among those enrolled.

What I am trying to establish is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything. Happy to be told the question itself is wrong.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
3 23Dr.RenalNash, LipidDoc_ATL, BariatricNurseD
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PharmacoVig_BOS
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Jul 9, 2024 at 7:34 PM#2
FranDenver said:
Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body.

Plateau breaking story with a stall: I stalled at 207 lbs for 8 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: adding HIIT cardio 2x/week. Lost 6 lbs in the next 3 weeks. Plateaus are temporary — they always break if you stay consistent.

Last edited: Jul 9, 2024 at 10:34 PM
2 22Dr.GutHealth, amsterdam_pete
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SarahChen_PharmD
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Jul 9, 2024 at 7:51 PM#3
FranDenver said:
Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body.

I read this differently from FranDenver, on substance rather than tone. The "it is your intake" reflex here gets tiring. Some people genuinely stop responding at a dose that worked, and telling them to track harder when they have already tracked is how people stop posting.

Last edited: Jul 9, 2024 at 10:51 PM
1 21paul_denver
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chris_chi24
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Jul 9, 2024 at 8:08 PM#4

This one has a reasonably settled answer, so here it is. Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

Correct me if the detail matters more than I have assumed.

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PeptideSynthNJ
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Jul 9, 2024 at 9:38 PM#5
PharmacoVig_BOS said:
Plateau breaking story with a stall: I stalled at 207 lbs for 8 weeks.

This matches mine closely enough to be worth saying so out loud.

49 19Dr.RaviCardio, jennifer_SEA, tyler_CSCS and 46 others
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