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Evidence-based GLP-1 & peptide discussion since 2023
ForumsSide Effects & ManagementMuscle cramps on semaglutide — 6 month update Page 3

Muscle cramps on semaglutide — 6 month update

FDA_TrackerJim Tue, Jan 23, 2024 at 8:04 PM 17 replies 2,187 viewsPage 3 of 4
Dr.RenalNash
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Jan 25, 2024 at 5:46 AM#11
hans_munich said:
There is also a quality change that the scan cannot see.

That holds for the injectable. The oral formulation has different absorption behaviour and the dose numbers are not interchangeable, which is worth saying out loud because people quote them as if they were.

44 17wei_SG, cory_ATX, lori_vegas and 41 others
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denise_HTX
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Jan 26, 2024 at 4:34 AM#12
Dr.SurgeonPGH said:
Steady state is the thing most people miss.

That reframing is the part I needed. Taking it to my next appointment.

Last edited: Jan 26, 2024 at 6:34 AM
45 18NeuroNate, JessicaH_TX, KevinCompounds and 42 others
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MikeFit_NJ
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Jan 27, 2024 at 3:22 AM#13
hans_munich said:
There is also a quality change that the scan cannot see.

Pushing back on hans_munich here. The trial means are being read too generously in this thread. STEP populations were selected, supported, and titrated by protocol, and the real-world curves are consistently a few points worse. That difference is not noise, it is what happens when you remove the study infrastructure.

46 19DeniseRN_TPA, SandraNC_45, Dr.EndoIndy and 43 others
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BethLabQueen
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Jan 28, 2024 at 2:09 AM#14

One concrete data point for the thread. If you are tracking this properly: same scanner, same time of day, same hydration, at least six months apart, and read grip strength or a lift number alongside it. Function is the outcome; the scan is the proxy.

Last edited: Jan 28, 2024 at 3:09 AM
47 20cory_ATX, lori_vegas, Dr.PulmRoch and 44 others
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mike_mod
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Jan 29, 2024 at 12:56 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Thread quality here is what the rules are for. Keep it up.

48 21PurityPaulOR, MaxMetOK, MounjBrad and 45 others
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