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Evidence-based GLP-1 & peptide discussion since 2023
ForumsCOA & Analytical TestingHas anyone dealt with moisture content analysis for lyophilized peptides? Page 6

Has anyone dealt with moisture content analysis for lyophilized peptides?

NauseaFreeNow Sun, Mar 16, 2025 at 5:34 AM 42 replies 1,836 viewsPage 6 of 9
PeptideSynthNJ
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Apr 16, 2025 at 6:37 AM#26

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

13 11wanda_boise, NurseAsh_DET, BenResearch_OR and 10 others
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PurityPaulOR
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Apr 20, 2025 at 5:40 AM#27

One thing that is still open after pat_auckland’s answer:

What did you change at the same time, and can you separate the two now?

Last edited: Apr 20, 2025 at 8:40 AM
14 12MikeNYC_runner and 11 others
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SteveThurs
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Apr 24, 2025 at 4:45 AM#28
PeptideSynthNJ said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

Last edited: Apr 24, 2025 at 8:45 AM
15 13SleepFixSam, PurityPaulOR, MaxMetOK and 12 others
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Sigma-Aldrich — Research-Grade Standards

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Dr.ObesityLA
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Apr 28, 2025 at 3:52 AM#29
PeptideSynthNJ said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

No disagreement, though the timescale matters more than the mechanism here. Most of what looks like a difference in kind turns out to be a difference in how long somebody waited.

16 14chris_chi24, tampaLisa73, KarenAZ_mom and 13 others
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NauseaFreeNow
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May 2, 2025 at 3:02 AM#30

Reporting back.

Update: the thing I was blaming turned out not to be the cause. Leaving the original post as written rather than editing it, so the mistake stays visible for whoever searches this next.

38 11cory_ATX, lori_vegas, Dr.PulmRoch and 35 others
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