🍪 CompoundTalk uses cookies to improve your experience, analyze traffic, and personalize content. By continuing to use this site, you agree to our Cookie Policy.
Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab ResultsHas anyone dealt with [premium] couple's transformation?

Has anyone dealt with [premium] couple's transformation?

marco_milano Fri, Mar 22, 2024 at 5:46 AM 42 replies 2,236 viewsPage 1 of 9
This thread is more than 26 months old. Information may be outdated. Consider searching for more recent discussions.
marco_milano
Member
345
1,456
Jul 2024
Milan, IT
Mar 22, 2024 at 5:46 AM#1

Read the primary source rather than the write-up and the two do not agree, so here is what is actually in it.

Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body. A body 20kg lighter needs meaningfully fewer calories at rest and less to move, so the deficit that produced the first phase is arithmetically smaller now. The options are the honest ones — increase the deficit slightly, increase activity, or accept the new plateau — and escalating the dose is only one of them.

Where I think it is weakest: the comparator does most of the work in how this gets reported, and it is not the comparator most people think they are citing.

What I am trying to establish is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything. I have searched first, so if this is covered somewhere point me at it and I will read it.

Note on sourcing:
Figures above are from the primary publication rather than the press summary. If a number here disagrees with one you have, post yours and we will work out which of us is reading a secondary source.
17 12kevin_tulsa, Dr.PainCLE, mike_mealprep and 14 others
Reply Quote Save Share Report
Dr.SleepRoch
Senior Member
1,123
5,678
Apr 2024
Rochester, MN
Mar 22, 2024 at 7:56 AM#2
marco_milano said:
Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body.

Plateau breaking story with a stall: I stalled at 203 lbs for 6 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: increasing protein to 150g/day. Lost 9 lbs in the next 2 weeks. Plateaus are temporary — they always break if you stay consistent.

16 11kim_atl_prep, sarah_TO, wendy_avl and 13 others
Reply Quote Save Share Report
DanielChem_CHI
Senior Member
1,234
5,678
Mar 2024
Chicago, IL
Mar 22, 2024 at 10:06 AM#3
marco_milano said:
Genuine plateaus happen too, and the mechanism is metabolic adaptation plus a smaller body.

This is where I part company with the consensus forming above. The "it is your intake" reflex here gets tiring. Some people genuinely stop responding at a dose that worked, and telling them to track harder when they have already tracked is how people stop posting.

Ask again with the specifics and you will get a better answer than this one.

Last edited: Mar 22, 2024 at 12:06 PM
15 10patPC_UT, Dr.DermMIA, fiona_VT and 12 others
Reply Quote Save Share Report

Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

Shop Reference Standards
paige_pharma
Member
289
1,234
Sep 2024
Omaha, NE
Mar 22, 2024 at 12:15 PM#4

This one has a reasonably settled answer, so here it is. Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

14 9lisa_labSD, adam_van, Dr.SurgeonPGH and 11 others
Reply Quote Save Share Report
SleepDoc_PDX
Member
289
1,234
Sep 2024
Portland, OR
Mar 23, 2024 at 1:05 AM#5
Dr.SleepRoch said:
Plateau breaking story with a stall: I stalled at 203 lbs for 6 weeks.

Adding a me-too, because a thread of one person's experience is not much use.

Last edited: Mar 23, 2024 at 4:05 AM
13 8mel_PDX, Dr.AddMedPHL, newstart_MO and 10 others
Reply Quote Save Share Report

Amazing transformation! Starting at 287 lbs, I'm now at 162 lbs after 18 months on semaglutide 2.4mg/wk. These photos show my progress at months 3, 6, 9, 12, 15, and 18. The body recomposition has been incredible — DEXA shows 23% body fat, down from 42%...

Premium Content

Progress photos are available to Premium subscribers only

Subscribe — $4.99/mo
1239

Similar Threads

100 lbs lost in 14 months — comprehensive DEXA and lab data16 replies
12-month metabolic panel comparison — before and after GLP-122 replies
A1C from 9.2 to 5.4 in 8 months — my diabetes reversal journey16 replies
6-month body recomposition — DEXA, labs, progress photos22 replies
1-year semaglutide anniversary — honest review with all data16 replies
ForumsNewTrendingMembersAccount

Log In

Forgot password?
No account? Register