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Evidence-based GLP-1 & peptide discussion since 2023
ForumsProgress & Lab Results[PREMIUM] From wheelchair-bound to hiking again — need advice

[PREMIUM] From wheelchair-bound to hiking again — need advice

mel_PDX Thu, Feb 22, 2024 at 2:32 PM 15 replies 2,263 viewsPage 1 of 3
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mel_PDX
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Feb 22, 2024 at 2:32 PM#1

Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several times.

The narrow version of the question is how to distinguish a genuine plateau from measurement noise and creeping intake, before changing anything.

I would rather have one careful answer than five confident ones.

8 3Dr.NateNeph, PharmD_Rodriguez, julia.endo and 5 others
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amsterdam_pete
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Feb 22, 2024 at 3:56 PM#2
mel_PDX said:
Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Plateau breaking story with a stall: I stalled at 205 lbs for 6 weeks. Tried everything — calorie cycling, increased exercise, more water. Nothing worked.

What finally broke the plateau: increasing protein to 150g/day. Lost 5 lbs in the next 2 weeks. Plateaus are temporary — they always break if you stay consistent.

Last edited: Feb 22, 2024 at 9:56 PM
7 2ZaraB_AL, JakeSmashed95, NauseaFreeNow and 4 others
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JenPlateau
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Feb 22, 2024 at 5:20 PM#3
amsterdam_pete said:
Plateau breaking story with a stall: I stalled at 205 lbs for 6 weeks.

amsterdam_pete has the substance of this right. The condition it depends on is worth stating. Most reported plateaus are not plateaus. Weight is a noisy signal — daily variation of one to two kilograms from glycogen, sodium and gut contents — so a fortnight of flat readings is well inside the noise band. Before concluding anything, look at a rolling weekly average over at least four weeks and at a tape measure, because recomposition shows up in circumference before it shows up in weight. Then track intake honestly for a week: appetite suppression fades unevenly, and intake creeping back up is the single commonest cause.

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traveltech_sara
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Feb 22, 2024 at 6:44 PM#4
mel_PDX said:
Thirteen weeks at the same dose with no change on the scale, and I have gone from assuming it was the drug to assuming it was me and back several…

Can confirm. Same sequence, different timescale.

Last edited: Feb 22, 2024 at 9:44 PM
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Dr.EM_Chicago
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Feb 23, 2024 at 2:53 AM#5

Adding the clinical framing, because it changes how the question reads. The honest answer is that the effect is real, the magnitude is contested, and the individual variation is larger than either. Those three things can all be true at once, and most arguments here are two people holding different parts of that.

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