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ForumsCOA & Analytical TestingPaid for independent testing and results did not match vendor COA — looking for input Page 3

Paid for independent testing and results did not match vendor COA — looking for input

LarryQC_SD Thu, Dec 5, 2024 at 10:18 PM 16 replies 1,934 viewsPage 3 of 4
Dr.GastroMayo
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Dec 7, 2024 at 9:56 PM#11
Dr.NutriCornell said:
They are not contradictory, they measure different things, and this is the single most common misreading of a certificate.

Agreed, and mass spec answers a question purity does not: identity. High purity tells you one thing dominates the chromatogram, not that it is the molecule you ordered. A mass within about a dalton of expected is the identity check.

Last edited: Dec 8, 2024 at 2:56 AM
44 17mike_nyc, VendorMark, COA_Karl and 41 others
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cory_ATX
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Dec 9, 2024 at 4:52 AM#12
SandraNC_45 said:
Right, and one flattering data point from a group buy is not consistency.

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

45 18andrew_nyc, Dr.EndoEP, GraceAZ_72 and 42 others
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maria_elpaso
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Dec 10, 2024 at 11:48 AM#13
Dr.NutriCornell said:
They are not contradictory, they measure different things, and this is the single most common misreading of a certificate.

I am more sceptical of certificates as a category than this thread is. The document tells you about a sample somebody chose to send, at a moment in time, and nothing about the vial in your hand. Independent purchase-and-test is a different quality of evidence and everything else is inference.

46 19TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 43 others
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Sigma-Aldrich — Research-Grade Standards

Certified reference materials, analytical reagents, and research-grade standards for peptide verification. Trusted by laboratories worldwide.

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kate.chem
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Dec 11, 2024 at 6:45 PM#14
LarryQC_SD said:
Six orders from the same supplier over eight months, every one independently tested, and the consistency is the part worth reporting rather than any…

Shipping damage protocol for vendor vetting orders: if your package arrives with visible damage, temperature excursion, or broken vials:

  • Photograph EVERYTHING before discarding packaging
  • Note the temperature of the cold pack (liquid = possibly too warm)
  • Contact the vendor within 24 hours with photos
  • Request a replacement shipment or refund
  • Do NOT use potentially compromised medication

Reputable vendors will replace damaged shipments without argument. If they push back, that's a red flag about the vendor.

47 20jennifer_SEA, tyler_CSCS, VanRx_Mike and 44 others
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mike_mod
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Dec 13, 2024 at 1:43 AM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Tagging this one for the weekly digest.

48 21PurityPaulOR, MaxMetOK, MounjBrad and 45 others
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