PharmacoVig_BOS said:

The mechanism and the magnitude are separate questions.

True, with the qualification that this is a self-selected group. The people for whom it did not work post less, and that shapes everything we think we know.

Dr.SportsMedIN said:

Agreed on the target, with the caveat that reference weight and current weight are different numbers.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. Printing the relevant bit and taking it with me.

PharmacoVig_BOS said:

The mechanism and the magnitude are separate questions.

I read this differently from PharmacoVig_BOS, on substance rather than tone. Pushing back on the anecdote-stacking. Twenty people reporting the same thing is twenty samples from the same self-selected pool, not twenty independent confirmations.

One concrete data point for the thread. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. Report rather than reply if it drifts again.