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Evidence-based GLP-1 & peptide discussion since 2023
ForumsVendor ReviewsI made a spreadsheet comparing vendor COAs — anyone have experience? Page 4

I made a spreadsheet comparing vendor COAs — anyone have experience?

JennaRN Fri, Mar 22, 2024 at 2:29 AM 36 replies 2,800 viewsPage 4 of 8
DanielChem_CHI
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Mar 27, 2024 at 1:31 AM#16
chris_chi24 said:
Vendor reputation tracking for vendor vetting: I maintain a personal spreadsheet with every order I've placed — date, vendor, batch number, Janoshik…

Can confirm the pattern chris_chi24 describes. One addition: an unstated method makes a report close to uninterpretable. "99% pure" without the technique, the standard and the conditions is a claim, not a measurement.

Worth separating that from certificates of analysis, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Mar 27, 2024 at 3:31 AM
32 7fiona_VT, denise_HTX, raj_cambridge and 29 others
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pete_RVA
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Mar 27, 2024 at 2:47 PM#17
TrialTracker_MD said:
Shipping damage protocol for vendor vetting orders: if your package arrives with visible damage, temperature excursion, or broken vials: Photograph…

Adding the part of the answer the thread has not reached. Inter-laboratory variation comes from real methodological differences, not sloppiness: which reference standard was used and how it was itself calibrated, the gradient and column, the detection wavelength, and where the integration baseline was drawn. A percentage point or two between competent labs is expected. What is not expected is a large gap, and the usual explanation there is that one report is not of the batch in your hand.

31 6Dr.Martinez, mike_mod, SarahChen_PharmD and 28 others
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hank_denver
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Mar 28, 2024 at 4:03 AM#18

One concrete data point for the thread. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

30 5denise_HTX, raj_cambridge, ingrid_STO and 27 others
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SaraMom3
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Mar 28, 2024 at 5:18 PM#19

One thing that is still open after TrialTracker_MD’s answer:

Why two laboratories report different purity for the same batch, and which number to believe?

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mike_mod
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Mar 29, 2024 at 6:33 AM#20

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part. No action needed from anybody.

7 7PurityPaulOR, MaxMetOK, MounjBrad and 4 others
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