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ForumsVendor ReviewsI made a spreadsheet comparing vendor COAs — anyone have experience? Page 5

I made a spreadsheet comparing vendor COAs — anyone have experience?

JennaRN Fri, Mar 22, 2024 at 2:29 AM 36 replies 2,800 viewsPage 5 of 8
pete_manc_UK
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Mar 29, 2024 at 7:42 PM#21
hank_denver said:
One habit that pays for itself: post the method alongside the number.

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Correct me if the detail matters more than I have assumed.

6 6TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 3 others
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lisa_labSD
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Oct 2024
San Diego, CA
Mar 31, 2024 at 9:26 PM#22
hank_denver said:
One habit that pays for itself: post the method alongside the number.

Bookmarking. The distinction being drawn above is the one nobody else makes. Taking it to my next appointment.

Last edited: Apr 1, 2024 at 12:26 AM
5 5maya_sedona, stefan_berlin, Dr.EM_Chicago and 2 others
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Dr.DermMIA
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Miami, FL
Apr 2, 2024 at 11:09 PM#23

Clinical perspective, offered as context rather than as advice. The mechanism and the magnitude are separate questions. Agreeing that something happens says nothing about whether it happens enough to act on.

Worth separating that from certificates of analysis, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

4 4A1cHero_PHX, Dr.RenalNash, LipidDoc_ATL and 1 other
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Dr.MetabolicMD
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Apr 5, 2024 at 12:51 AM#24
Dr.DermMIA said:
The mechanism and the magnitude are separate questions.

This matches mine closely enough to be worth saying so out loud.

3 3Dr.ObesityMed, HealthEcon_DC, PedsEndoPhilly
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HealthEcon_DC
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Apr 7, 2024 at 2:31 AM#25
Dr.DermMIA said:
The mechanism and the magnitude are separate questions.

Adding the part of the answer the thread has not reached. They are not contradictory, they measure different things, and this is the single most common misreading of a certificate. Purity is a relative area measurement: the main peak as a percentage of total peak area in the chromatogram. Content is an absolute mass measurement against a reference standard. A vial can be 99% pure and contain 6.1mg — pure material, overfilled — or 99% pure and contain 3mg, which is pure material and a short fill. Purity tells you what fraction of what is there is the right molecule; content tells you how much of it there is. You need both, and a certificate with only purity is telling you half the story.

Worth separating that from certificates of analysis, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Apr 7, 2024 at 4:31 AM
2 2TrialTracker_MD, JennaRN
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