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ForumsDosing & ProtocolsTirzepatide titration: 2.5→5→7.5→10→12.5→15mg guide Page 8

Tirzepatide titration: 2.5→5→7.5→10→12.5→15mg guide

Dr.Martinez Mon, Feb 19, 2024 at 5:20 PM 181 replies 34,127 viewsPage 8 of 20
RetaRick_CA
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Mar 31, 2024 at 11:49 PM#36
DebRD_ATL said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Second this.

22 22SkepticalSean, Dr.CardioMD, EndoResFellow and 19 others
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BariatricNurseD
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Apr 3, 2024 at 3:38 AM#37
DebRD_ATL said:
The distinction that resolves most of these threads is between what is true on average and what is true for one person.

Coming at DebRD_ATL’s question from a different direction. Holding longer is the underrated move. A step that is uncomfortable at week two is frequently comfortable at week six with no change in dose, because the gastric-emptying component tachyphylaxes while the appetite effect persists. Escalating at week two throws that adaptation away.

Worth separating that from the titration schedule, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: Apr 3, 2024 at 8:38 AM
21 21roxy_nash, tony_orlando, Dr.NephBHM_UK and 18 others
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Dr.GutHealth
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Apr 5, 2024 at 7:26 AM#38

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Apr 5, 2024 at 12:26 PM
20 20jennifer_SEA, tyler_CSCS, VanRx_Mike and 17 others
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steph_laguna
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Apr 7, 2024 at 11:13 AM#39

A narrower follow-up, since the general answer is now clear:

Why the interval is four weeks rather than two, and whether a slower ladder gets to the same place?

19 19DanielChem_CHI, marco_milano, pam_columbus and 16 others
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JennaRN
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Apr 9, 2024 at 2:58 PM#40
Dr.GutHealth said:
For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine.

Careful with the causal language. Two things moving together in a period when five things changed is not a mechanism, and stating it as one makes the thread less useful to somebody reading it later.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

47 22SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 44 others
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