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ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — my results so far Page 3

Adiponectin and leptin changes on GLP-1 therapy — my results so far

rachel_ABQ Mon, Apr 13, 2026 at 5:12 AM 12 replies 812 viewsPage 3 of 3
Dr.MetabolicMD
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Apr 15, 2026 at 10:26 AM#11
james_edin said:
Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 2.

Anxiety increase on mental health: counterintuitive, but losing weight rapidly triggered anxiety for me. Change — even positive change — is stressful. I was anxious about people treating me differently.

This is more common than people admit. A therapist who specializes in weight management has been invaluable. Don't neglect the mental health side of this journey.

16 14SleepDoc_PDX, RegAffairsDC, BiostatsBrad and 13 others
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oliver_london
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Apr 17, 2026 at 6:38 AM#12
paige_pharma said:
When to call your doctor about mental health side effects — a reference I wish I'd had: Call immediately: Severe abdominal pain (could be…

This is exactly what I could not find anywhere else. Adding it to my notes with a link back to this thread.

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hank_denver
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Apr 19, 2026 at 2:49 AM#13
james_edin said:
Mood changes on mental health: I want to be transparent — I went through a rough patch emotionally around month 2.

Positive side effects of mental health that surprised me:

  1. Clearer skin — inflammation reduction improved my rosacea
  2. Better sleep — weight loss resolved mild sleep apnea
  3. Improved libido — better body image + improved cardiovascular health
  4. Less joint pain — obvious mechanical benefit
  5. More energy — metabolic improvements across the board

Not everything about GLP-1 therapy is a struggle. There are genuinely wonderful changes too. ✨

Last edited: Apr 19, 2026 at 6:49 AM
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stefan_berlin
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Apr 20, 2026 at 10:59 PM#14
rachel_ABQ said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

One year anniversary on mental health — reflections:

What I wish I'd known: the side effects are temporary, the benefits compound over time, protein is more important than I thought, and the mental health aspect needs as much attention as the physical.

What surprised me: how much my relationship with food changed, the cascade of health improvements beyond weight, and how supportive this community is.

What I'd do differently: start therapy earlier, prioritize resistance training from day 1, and stop comparing my progress to others. Everyone's journey is unique.

19 17TirzTom, TrialTracker_MD, JennaRN and 16 others
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mike_mod
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Apr 22, 2026 at 7:08 PM#15

Moderator note: reminder that nothing in this thread is medical advice, and that clinical claims need a source. No action needed from anybody.

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