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ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — my results so far

Adiponectin and leptin changes on GLP-1 therapy — my results so far

rachel_ABQ Mon, Apr 13, 2026 at 5:12 AM 12 replies 812 viewsPage 1 of 3
rachel_ABQ
Member
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Dec 2024
Albuquerque, NM
Apr 13, 2026 at 5:12 AM#1

The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

The bit I cannot resolve on my own is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Numbers rather than impressions, if you have them.

27 22nick_newbie, DadBodDave, AmyNC_wife and 24 others
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PharmD_Rodriguez
Senior Member
3,456
14,567
Jan 2024
Miami, FL
Apr 13, 2026 at 5:22 AM#2
rachel_ABQ said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Before/after narrative for mental health — one year in:

Before (296 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (191 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 96 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

Last edited: Apr 13, 2026 at 10:22 AM
26 21TinaHashiRN, robert_kc, dan_philly and 23 others
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paige_pharma
Member
289
1,234
Sep 2024
Omaha, NE
Apr 13, 2026 at 5:32 AM#3
PharmD_Rodriguez said:
Before/after narrative for mental health — one year in: Before (296 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications,…

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
25 20adam_van, Dr.SurgeonPGH, rachel_ABQ and 22 others
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quinn_sf
Member
489
2,123
Jun 2024
San Francisco, CA
Apr 13, 2026 at 5:42 AM#4
rachel_ABQ said:
The weight came off and the harder part started, which is not what any of the material I read had prepared me for.

Same experience, arrived at from the opposite direction.

Last edited: Apr 13, 2026 at 11:42 AM
24 19andrew_nyc, Dr.EndoEP, GraceAZ_72 and 21 others
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Dr.RheumBOS
Member
567
2,345
Apr 2024
Boston, MA
Apr 13, 2026 at 6:34 AM#5

From the other side of the consultation, briefly.

Therapy insights from my mental health journey: my therapist introduced me to the concept of "identity updating" — the psychological work of becoming a new version of yourself.

Key realizations: I used food to manage emotions, I had internalized fatphobia that I'm still unpacking, my social identity was partly built around being "the big guy/girl," and learning to accept compliments is surprisingly hard when you've been invisible for years.

Physical transformation without emotional processing is unstable. Do both.

Last edited: Apr 13, 2026 at 12:34 PM
23 18Dr.PulmRoch, maya_sedona, stefan_berlin and 20 others
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