Dr.ObesityMed said:Dose-response modeling for tirzepatide: Emax model fitting to the STEP/SURMOUNT dose-finding data shows: Semaglutide: ED50 ≈ 0.6mg, Emax ≈ -18%, Hill…
Second this.
One thing that is still open after Dr.LipidDallas’s answer:
How much of the SELECT benefit is plausibly independent of the weight loss, and whether that distinction changes anything practical?
Dr.GutHealth said:One practical note: write down what you did and when, before you need it.
I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.
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Shop Reference StandardsDr.GutHealth said:One practical note: write down what you did and when, before you need it.
Correct as far as it goes. The part it does not cover is what to do when the honest answer is "not enough data", which is more often than anyone likes.
Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.