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ForumsMetabolic Health & DiabetesSURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — need advice Page 5

SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — need advice

GenomicsKate Sat, Jan 3, 2026 at 11:59 AM 29 replies 1,587 viewsPage 5 of 6
Dr.ObesityLA
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Jan 17, 2026 at 3:46 PM#21

Clinical perspective, offered as context rather than as advice. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.

20 18zoe_NC, Dr.ObesityLA, NurseKim_ATL and 17 others
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quinn_sf
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Jan 22, 2026 at 4:58 AM#22
Dr.ObesityLA said:
The version of this that has an answer is narrower than the version being asked.

Same experience, arrived at from the opposite direction.

21 19Dr.PathRoch, mona_PHX, andrew_nyc and 18 others
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PeptideSynthNJ
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Jan 26, 2026 at 6:08 PM#23
Dr.ObesityLA said:
The version of this that has an answer is narrower than the version being asked.

Coming at Dr.ObesityLA’s question from a different direction. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.

Last edited: Jan 26, 2026 at 10:08 PM
22 20BenResearch_OR, MikeKY_noInsulin, Dr.RaviCardio and 19 others
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hank_denver
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Jan 31, 2026 at 7:15 AM#24

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

23 21fiona_VT, denise_HTX, raj_cambridge and 20 others
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rachel_ABQ
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Feb 4, 2026 at 8:19 PM#25

One thing that is still open after Dr.ObesityLA’s answer:

How long did you give it before you decided it was working?

24 22Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 21 others
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