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ForumsPharmacology & MechanismsHas anyone dealt with molecular dynamics simulations of glp-1r binding? Page 8

Has anyone dealt with molecular dynamics simulations of glp-1r binding?

BrianDallas92 Wed, Apr 16, 2025 at 2:37 AM 36 replies 1,942 viewsPage 8 of 8
amsterdam_pete
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Nov 18, 2025 at 7:26 AM#36
TinaHashiRN said:
It helps to say which part of this you are uncertain about.

Coming at TinaHashiRN’s question from a different direction. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

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hank_denver
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Nov 30, 2025 at 1:31 PM#37

The figures, for anyone assembling their own picture. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

I would rather be corrected than agreed with, if it comes to it.

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Dr.RheumBOS
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Dec 12, 2025 at 7:29 PM#38

One thing that is still open after TinaHashiRN’s answer:

How long did you give it before you decided it was working?

Last edited: Dec 13, 2025 at 1:29 AM
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Dr.PathRoch
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Dec 25, 2025 at 1:20 AM#39
hank_denver said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

This is where I part company with the consensus forming above. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

Ask again with the specifics and you will get a better answer than this one.

Last edited: Dec 25, 2025 at 7:20 AM
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MikeFit_NJ
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Jan 6, 2026 at 7:04 AM#40
hank_denver said:
Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a…

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

32 5Dr.EndoIndy, tom_AK, josh_phd_bmore and 29 others
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