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ForumsPharmacology & MechanismsHas anyone dealt with molecular dynamics simulations of glp-1r binding? Page 7

Has anyone dealt with molecular dynamics simulations of glp-1r binding?

BrianDallas92 Wed, Apr 16, 2025 at 2:37 AM 36 replies 1,942 viewsPage 7 of 8
jim_asheville
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Sep 17, 2025 at 11:14 PM#31
BrianDallas92 said:
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The counter-case has not been addressed. Somebody upthread described the situation that does not fit, and the thread moved on rather than engaging with it, which is the failure mode this board is supposed to avoid.

2 0MikeKY_noInsulin, Dr.RaviCardio
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HPLC_Greg
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Sep 30, 2025 at 5:55 AM#32
BrianDallas92 said:
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

That is right, and it stops being right at the edges. The general case is well behaved; the interesting cases in this thread are all at the boundary where the general case breaks.

3 1JenPlateau, SallyK_inj, CryptoCarl
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KarenAZ_mom
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Oct 12, 2025 at 12:29 PM#33
BrianDallas92 said:
Update — tachyphylaxis to the gastric effect, persistence of the appetite effect.

This is exactly what I could not find anywhere else. Printing the relevant bit and taking it with me.

Last edited: Oct 12, 2025 at 5:29 PM
4 2bri_stats, pete_manc_UK, anna.melb_AU and 1 other
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TinaHashiRN
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Oct 24, 2025 at 6:55 PM#34

Adding the clinical framing, because it changes how the question reads. It helps to say which part of this you are uncertain about. A precise question gets a precise answer; a general one gets everybody’s favourite anecdote.

Last edited: Oct 25, 2025 at 12:55 AM
5 3Admin, Dr.Martinez, mike_mod and 2 others
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LindaRN_retired
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Nov 6, 2025 at 1:14 AM#35
TinaHashiRN said:
It helps to say which part of this you are uncertain about.

Adding a me-too, because a thread of one person's experience is not much use. Posting only so the count is not one.

6 4mike_nyc, VendorMark, COA_Karl and 3 others
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