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ForumsMetabolic Health & DiabetesSURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — looking for input Page 8

SURPASS-CVOT: tirzepatide cardiovascular outcomes trial design — looking for input

Admin Sat, Jul 12, 2025 at 7:09 AM 40 replies 1,896 viewsPage 8 of 8
anders_CPH
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Mar 5, 2026 at 6:39 PM#36
ingrid_STO said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Same pattern here, and in the same order. The detail I would add is minor and it is already implied above.

38 11CryptoCarl, MariaRD, AussieAnna and 35 others
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DanielChem_CHI
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Mar 19, 2026 at 4:52 AM#37
ingrid_STO said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Coming at ingrid_STO’s question from a different direction. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

Last edited: Mar 19, 2026 at 6:52 AM
39 12Dr.DermMIA, fiona_VT, denise_HTX and 36 others
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wendy_avl
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Asheville, NC
Apr 1, 2026 at 2:58 PM#38

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

40 13TomTeleRx, DoseLogDan, SleepFixSam and 37 others
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LeilaHI
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Apr 15, 2026 at 12:56 AM#39

Following on from ingrid_STO — and this may be the naive question:

What did you change at the same time, and can you separate the two now?

Last edited: Apr 15, 2026 at 5:56 AM
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josh_phd_bmore
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Apr 28, 2026 at 10:46 AM#40
wendy_avl said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Pushing back on wendy_avl here. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

Ask again with the specifics and you will get a better answer than this one.

13 11tampaLisa73, KarenAZ_mom, zoe_NC and 10 others
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