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ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — September 2026 Page 2

Adiponectin and leptin changes on GLP-1 therapy — September 2026

InsuranceTom Sat, Jun 14, 2025 at 11:06 AM 6 replies 1,314 viewsPage 2 of 2
Dr.AddMedPHL
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Jun 15, 2025 at 11:51 AM#6
NurseKim_ATL said:
Body image adjustment with mental health: I've lost 56 lbs but when I look in the mirror, I still see my old self sometimes.

Pushing back on NurseKim_ATL here. I would be careful about how confidently the flatness reports get attributed. Rapid weight loss, a large deficit and disrupted sleep produce low mood on their own, and separating that from a drug effect is genuinely hard.

25 20FitDadDave, RunnerRach, TrialNerd_Beth and 22 others
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VendorMark
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Jun 15, 2025 at 9:41 PM#7
InsuranceTom said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…
InsuranceTom said:
...mental health should only be used alongside therapy...

I'd say therapy should be AVAILABLE to all GLP-1 patients, but requiring it as a precondition for treatment would create an access barrier.

Not everyone can afford therapy. Not everyone needs it. Some people do just fine with medication + lifestyle changes. But for those with emotional eating, body image issues, or disordered eating history, therapy is extremely valuable.

My recommendation: make mental health screening part of the initial assessment, offer therapy as a recommended adjunct, but don't gatekeep medication access behind it.

Last edited: Jun 15, 2025 at 11:41 PM
24 19KristenIndy, MarkLI_maint, Dr.PeteFamMed and 21 others
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sean_dublin
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Jun 16, 2025 at 7:31 AM#8
Dr.AddMedPHL said:
I would be careful about how confidently the flatness reports get attributed.

When to call your doctor about mental health side effects — a reference I wish I'd had:

Call immediately:

  • Severe abdominal pain (could be pancreatitis)
  • Vision changes (thyroid concern)
  • Lump in neck (thyroid nodule)
  • Severe vomiting/can't keep fluids down for 24h+

Schedule an appointment:

  • Persistent nausea beyond 4 weeks
  • Significant hair loss
  • Mood changes or depression
  • Gallbladder symptoms (RUQ pain after eating)
Last edited: Jun 16, 2025 at 8:31 AM
23 18gary_naperville, sean_dublin, hannah_MT and 20 others
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pete_RVA
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Richmond, VA
Jun 16, 2025 at 5:21 PM#9

One thing that is still open after newstart_MO’s answer:

What would you measure differently if you were starting again?

22 17MikeNYC_runner and 19 others
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InsuranceTom
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Connecticut
Jun 18, 2025 at 4:31 PM#10

OP back with an update, since a thread like this is useless without one.

Follow-up — I put something in the gap where food used to be rather than waiting for the gap to close on its own. That was the part nobody told me.

Last edited: Jun 18, 2025 at 9:31 PM
42 15jim_asheville, matt_MKE, Dr.ReproEndo and 39 others
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