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ForumsMetabolic Health & DiabetesAdiponectin and leptin changes on GLP-1 therapy — September 2026

Adiponectin and leptin changes on GLP-1 therapy — September 2026

InsuranceTom Sat, Jun 14, 2025 at 11:06 AM 6 replies 1,314 viewsPage 1 of 2
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InsuranceTom
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Mar 2024
Connecticut
Jun 14, 2025 at 11:06 AM#1

My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer have my main coping mechanism.

What I am after is how people separated a drug effect from the ordinary consequences of a large deficit and disrupted sleep, because I cannot.

Happy to be told the question itself is wrong.

30 0lisa_labSD, adam_van, Dr.SurgeonPGH and 27 others
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NurseKim_ATL
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Feb 2024
Atlanta, GA
Jun 14, 2025 at 12:47 PM#2
InsuranceTom said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Body image adjustment with mental health: I've lost 56 lbs but when I look in the mirror, I still see my old self sometimes. "Phantom fat" is a real phenomenon.

My therapist specializes in body image issues with weight loss patients. She says it can take 12-18 months for your brain's body map to update. In the meantime: take progress photos (your eyes lie but cameras don't), try on old clothes, and be patient with yourself.

Last edited: Jun 14, 2025 at 5:47 PM
29 24raj_cambridge, ingrid_STO, pete_nash and 26 others
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newstart_MO
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Feb 2026
Springfield, MO
Jun 14, 2025 at 2:28 PM#3
NurseKim_ATL said:
Body image adjustment with mental health: I've lost 56 lbs but when I look in the mirror, I still see my old self sometimes.

One year anniversary on mental health — reflections:

What I wish I'd known: the side effects are temporary, the benefits compound over time, protein is more important than I thought, and the mental health aspect needs as much attention as the physical.

What surprised me: how much my relationship with food changed, the cascade of health improvements beyond weight, and how supportive this community is.

What I'd do differently: start therapy earlier, prioritize resistance training from day 1, and stop comparing my progress to others. Everyone's journey is unique.

28 23HPLC_Greg, LibrarianMeg, bri_stats and 25 others
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GraceAZ_72
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Jan 2025
Tucson, AZ
Jun 14, 2025 at 4:09 PM#4
InsuranceTom said:
My mood has been flatter since about month four and I genuinely cannot work out whether that is the drug, the deficit, or the fact that I no longer…

Adding a me-too, because a thread of one person's experience is not much use. Posting only so the count is not one.

Last edited: Jun 14, 2025 at 8:09 PM
27 22JenPlateau, SallyK_inj, CryptoCarl and 24 others
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TrialNerd_Beth
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Bethesda, MD
Jun 15, 2025 at 2:00 AM#5

From the other side of the consultation, briefly.

Before/after narrative for mental health — one year in:

Before (256 lbs): Winded climbing stairs, chronic back pain, pre-diabetic, on 3 medications, dreaded mirrors, avoided photos, social anxiety about my weight.

After (186 lbs): Run 3 miles regularly, pain-free, A1C normal, down to 1 medication, bought a swimsuit for the first time in a decade, actually enjoy being photographed.

Total weight lost: 71 lbs. Total life gained: immeasurable. This isn't just about weight — it's about reclaiming your identity.

26 21SleepFixSam, PurityPaulOR, MaxMetOK and 23 others
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