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ForumsPharmacology & MechanismsStructure-activity relationships of GLP-1 analogs — anyone have experience? Page 3

Structure-activity relationships of GLP-1 analogs — anyone have experience?

sarah_TO Wed, Oct 30, 2024 at 10:31 PM 32 replies 1,968 viewsPage 3 of 7
Dr.AddMedPHL
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Nov 3, 2024 at 10:30 PM#11
Dr.NutriCornell said:
PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

6 4FitDadDave, RunnerRach, TrialNerd_Beth and 3 others
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hans_munich
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Nov 4, 2024 at 11:20 AM#12
PeptideChemSF said:
The mechanism is more central than most summaries suggest.

Thank you — that is the clearest version of this I have read, and I have read a lot of them. I will report back once I have actually tried it.

7 5alex_tucson, kevin_tulsa, Dr.PainCLE and 4 others
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Dr.NateNeph
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Nov 5, 2024 at 12:10 AM#13
Dr.NutriCornell said:
PK/PD modeling for the pharmacology: understanding the pharmacokinetics helps optimize dosing.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

8 6SteveThurs, B12Beth, RickReta_CO and 5 others
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DataDave
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Nov 5, 2024 at 1:00 PM#14

Adding the numbers, since they settle part of this. Keep the original post as written when you update it, and add the correction underneath. An edited-away mistake is invisible to the next person who makes it.

Last edited: Nov 5, 2024 at 2:00 PM
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Admin
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Nov 6, 2024 at 1:49 AM#15

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful.

10 8PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 7 others
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