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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsMolecular dynamics simulations of GLP-1R binding — anyone have experience? Page 3

Molecular dynamics simulations of GLP-1R binding — anyone have experience?

SkepticalSean Mon, Jul 22, 2024 at 8:00 AM 47 replies 3,019 viewsPage 3 of 10
DanielChem_CHI
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Jul 22, 2024 at 3:10 PM#11
james_edin said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Agreed, and the size of the effect matters as much as its existence. Something real and small gets treated here as though it were real and decisive.

Last edited: Jul 22, 2024 at 5:10 PM
11 9fiona_VT, denise_HTX, raj_cambridge and 8 others
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NurseAsh_DET
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Jul 22, 2024 at 5:38 PM#12
traveltech_sara said:
The pharmacokinetics explain nearly every practical question asked here.

This answered a question I did not know how to ask. I will report back once I have actually tried it.

Last edited: Jul 22, 2024 at 11:38 PM
12 10ricardo_MIA, BrianDallas92, labquiet_amy and 9 others
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FitDadDave
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Jul 22, 2024 at 8:06 PM#13
james_edin said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

I read this differently from james_edin, on substance rather than tone. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

13 11sarah_TO, wendy_avl, jason_paloalto and 10 others
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quinn_sf
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Jul 22, 2024 at 10:33 PM#14

The figures, for anyone assembling their own picture. One practical note: write down what you did and when, before you need it. Reconstructing a timeline from memory three months later is how people end up unable to answer the one question that would have resolved it.

14 12andrew_nyc, Dr.EndoEP, GraceAZ_72 and 11 others
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mike_mod
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Jul 23, 2024 at 1:00 AM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Thread quality here is what the rules are for. Keep it up.

15 13PurityPaulOR, MaxMetOK, MounjBrad and 12 others
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