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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPharmacology & MechanismsIs there a simple version of how sema vs tirz are different — anyone have experience? Page 3

Is there a simple version of how sema vs tirz are different — anyone have experience?

tyler_CSCS Thu, Apr 4, 2024 at 6:23 PM 61 replies 3,286 viewsPage 3 of 13
anders_CPH
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Apr 6, 2024 at 9:43 PM#11
Dr.AddMedPHL said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

That is right for the common case. Whether it is right for the case being asked about depends on a detail that has not been given.

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maria_elpaso
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Apr 7, 2024 at 4:30 AM#12
NeuroNate said:
The pharmacokinetics explain nearly every practical question asked here.

This answered a question I did not know how to ask. I will report back once I have actually tried it.

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KetoKyle
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Apr 7, 2024 at 11:17 AM#13
Dr.AddMedPHL said:
Receptor pharmacology relevant to the pharmacology: semaglutide is a GLP-1R agonist with a C-18 fatty acid chain that enables albumin binding (>99%),…

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. Not convinced. The evidence being cited is consistent with the conclusion and also consistent with two other conclusions nobody has ruled out.

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kate.chem
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Apr 7, 2024 at 6:04 PM#14

One concrete data point for the thread. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

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Admin
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Apr 8, 2024 at 12:51 AM#15

Moderator note: a post naming a supplier has been edited. Discuss suppliers in the review sections, not here. Tagging this one for the weekly digest.

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