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Evidence-based GLP-1 & peptide discussion since 2023
ForumsMetabolic Health & DiabetesHOMA-IR tracking on GLP-1 — anyone have experience?

HOMA-IR tracking on GLP-1 — anyone have experience?

SandraNC_45 Sat, Aug 17, 2024 at 1:19 PM 11 replies 2,013 viewsPage 1 of 3
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SandraNC_45
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Sep 2024
Charlotte, NC
Aug 17, 2024 at 1:19 PM#1

One order arrived in nine days, one was held at the border for a fortnight, and one came back with a seizure notice. Same route, same declaration wording.

The bit I cannot resolve on my own is which of the variables in a cross-border order actually determine the outcome, and which are superstition.

Practical detail welcome, however dull — the duller the better.

14 9FranDenver, Dr.BariatricHTX, LindaRN_retired and 11 others
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Dr.SportsMedIN
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Feb 2024
Indianapolis, IN
Aug 17, 2024 at 1:35 PM#2

Short answer first, then the reasoning. HbA1c reflects roughly three months of average glycaemia weighted toward the most recent weeks, which is why repeating it at six weeks tells you very little. The improvement on this class comes from two directions — direct glucose-dependent insulin secretion and glucagon suppression, plus the indirect effect of weight loss on insulin sensitivity — and the second continues after the first has plateaued.

13 8lisa_labSD, adam_van, Dr.SurgeonPGH and 10 others
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roxy_nash
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Dec 2024
Nashville, TN
Aug 17, 2024 at 1:51 PM#3
Dr.SportsMedIN said:
HbA1c reflects roughly three months of average glycaemia weighted toward the most recent weeks, which is why repeating it at six weeks tells you very…

Agreed, with the caveat that HbA1c is unreliable in anaemia, haemoglobinopathies and recent blood loss, all of which are commoner than people assume. If it disagrees with fasting glucose or a CGM, that is worth chasing.

I would rather be corrected than agreed with, if it comes to it.

12 7tony_orlando, Dr.NephBHM_UK, kim_atl_prep and 9 others
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SaraMom3
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Aug 2024
Ohio
Aug 17, 2024 at 2:07 PM#4
SandraNC_45 said:
One order arrived in nine days, one was held at the border for a fortnight, and one came back with a seizure notice.

Same pattern here, and in the same order. Posting only so the count is not one.

11 6CanadaChris, ZaraB_AL, JakeSmashed95 and 8 others
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Dr.GutHealth
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Minnesota
Aug 17, 2024 at 3:34 PM#5

From the other side of the consultation, briefly.

My experience ordering cross-border ordering internationally: I've ordered from a UK pharmacy. Customs can be hit or miss.

Shipping time: 7-14 days
Customs clearance: smooth, no issues
Quality: Janoshik tested at 99.1% purity

International ordering adds complexity but can save 60-80% compared to US prices. Research your country's import laws first.

Last edited: Aug 17, 2024 at 8:34 PM
10 5MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 7 others
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