NurseLeah_Nash said:

The useful move here is to separate what is established from what is widely repeated.

Fair, and it stops being fair at the extremes. The middle of the range is well understood; the ends are where the honest answer is that nobody knows.

james_edin said:

Worth adding that the tablet is taken daily, so a missed dose costs far less than a missed weekly injection.

Genuinely useful, thank you. I had the facts and not the framework. Adding it to my notes with a link back to this thread.

NurseLeah_Nash said:

The useful move here is to separate what is established from what is widely repeated.

This is where I part company with the consensus forming above. This treats a plausible mechanism as a demonstrated one. Plausible is where you start looking, not where you stop.

One concrete data point for the thread. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

Moderator note: good thread. Keeping it here rather than moving it, because the question is general enough to be useful. Report rather than reply if it drifts again.