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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsDanuglipron dose optimization — my results so far Page 3

Danuglipron dose optimization — my results so far

josh_phd_bmore Fri, Sep 26, 2025 at 11:20 PM 14 replies 1,430 viewsPage 3 of 3
PurityPaulOR
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Sep 28, 2025 at 4:59 AM#11
newstart_MO said:
It helps to ask what evidence would change your mind before you look at any.

Correct, and worth adding that it is reversible. Nothing being described here is a one-way door, which changes how cautious it is reasonable to be.

26 1Dr.LeslieOBGYN, MikeNYC_runner and 23 others
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AmyNC_wife
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Sep 28, 2025 at 3:37 PM#12
mark_tokyo said:
The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.

This is exactly what I could not find anywhere else. Taking it to my next appointment.

25 0julia.endo, JessicaM_2024, TomFromTexas and 22 others
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MarkLI_maint
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Sep 29, 2025 at 2:15 AM#13
newstart_MO said:
It helps to ask what evidence would change your mind before you look at any.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. I think the framing smuggles in the conclusion. Ask it the other way round and the obvious answer reverses, which usually means the question is doing the work.

Last edited: Sep 29, 2025 at 7:15 AM
24 24HPLC_Greg, LibrarianMeg, bri_stats and 21 others
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bri_stats
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Sep 29, 2025 at 12:53 PM#14

Adding the numbers, since they settle part of this. For anyone reading later: the numbers in this thread are worth checking against a primary source before you act on them, including mine. Half the figures circulating in this community trace back to a secondary summary that dropped a qualifier.

Last edited: Sep 29, 2025 at 4:53 PM
23 23JessicaM_2024, TomFromTexas, mike.trainer_LA and 20 others
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mike_mod
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Sep 29, 2025 at 11:31 PM#15

Moderator note: leaving this open. It is being argued well and the disagreement is the useful part.

22 22PurityPaulOR, MaxMetOK, MounjBrad and 19 others
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