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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsSmall molecule vs peptide GLP-1 agonists — anyone have experience? Page 3

Small molecule vs peptide GLP-1 agonists — anyone have experience?

jason_paloalto Thu, Sep 18, 2025 at 10:31 PM 33 replies 1,842 viewsPage 3 of 7
PharmD_Rodriguez
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Sep 22, 2025 at 3:27 AM#11
Dr.ReproEndo said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

No disagreement, though it depends on where somebody is starting from, and this thread has been assuming a starting point nobody stated.

Last edited: Sep 22, 2025 at 8:27 AM
31 6paul_denver, TinaHashiRN, robert_kc and 28 others
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claudia_zurich
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Sep 23, 2025 at 7:29 AM#12
BenResearch_OR said:
Worth adding that the tablet is taken daily, so a missed dose costs far less than a missed weekly injection.

Genuinely useful, thank you. I had the facts and not the framework. Taking it to my next appointment.

30 5tammy_FL, Dr.LipidDallas, alex_tucson and 27 others
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kim_atl_prep
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Sep 24, 2025 at 11:31 AM#13
Dr.ReproEndo said:
There is a difference between no evidence and evidence of no effect, and this subject is one where the two get swapped freely in both directions.

I am going to disagree with the direction of travel here. The thread has converged on the tidiest answer rather than the best-supported one, and those are not the same thing.

29 4RegAffairsDC, BiostatsBrad, PeptideSynthNJ and 26 others
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Dr.PathRoch
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Rochester, MN
Sep 25, 2025 at 3:34 PM#14

The figures, for anyone assembling their own picture. One habit that pays for itself: post the method alongside the number. A figure without its method cannot be checked, and an unchecked figure is how this community accumulates folklore.

28 3SaraMom3, Dr.MetabolicMD, RetaRick_CA and 25 others
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mike_mod
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Sep 26, 2025 at 7:37 PM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. Carry on.

Last edited: Sep 26, 2025 at 9:37 PM
27 2PurityPaulOR, MaxMetOK, MounjBrad and 24 others
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