Adding the clinical framing, because it changes how the question reads. The version of this that has an answer is narrower than the version being asked. Narrow it and it becomes tractable; leave it broad and the thread will produce nine confident and incompatible replies.
From the other side of the consultation, briefly. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.
TrialTracker_MD said:If two explanations both fit, the useful question is which one predicts something the other does not.
Same pattern here, and in the same order. Nothing to add that would improve it.
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Shop Reference StandardsTrialTracker_MD said:If two explanations both fit, the useful question is which one predicts something the other does not.
There is a second half to this that has not been said yet. Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then measure again under the same conditions.
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