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ForumsPublic SquareMuscle protein synthesis rates on GLP-1 — leucine threshold discussion Page 5

Muscle protein synthesis rates on GLP-1 — leucine threshold discussion

ChrisMacros Mon, May 25, 2026 at 8:37 AM 21 replies 460 viewsPage 5 of 5
DanielChem_CHI
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May 30, 2026 at 12:17 PM#21
Dr.RaviCardio said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Saving this. It is the first explanation that did not require me to already understand it. Sending this to two other people who asked me the same thing last week.

23 21fiona_VT, denise_HTX, raj_cambridge and 20 others
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Dr.DermMIA
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Jun 1, 2026 at 2:09 PM#22

From the other side of the consultation, briefly. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

24 22Dr.RenalNash, LipidDoc_ATL, BariatricNurseD and 21 others
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sean_dublin
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Jun 3, 2026 at 4:03 PM#23
Dr.DermMIA said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Can confirm. Same sequence, different timescale. The detail I would add is minor and it is already implied above.

25 23gary_naperville, sean_dublin, hannah_MT and 22 others
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SteveThurs
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Jun 5, 2026 at 5:57 PM#24
Dr.DermMIA said:
Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the…

Coming at Dr.DermMIA’s question from a different direction. Worth answering the question that was asked rather than the one behind it. The narrow version usually has an answer; the broad version usually does not, and answering the broad one is how a thread stops being useful.

Last edited: Jun 5, 2026 at 9:57 PM
26 24DoseLogDan, SleepFixSam, PurityPaulOR and 23 others
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labquiet_amy
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Jun 7, 2026 at 7:53 PM#25

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

If somebody has the primary source to hand I would rather cite it than paraphrase it.

27 0pete_manc_UK, anna.melb_AU, mark_tokyo and 24 others
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