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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsPLEASE just give me a pill already I hate needles so much — looking for input Page 3

PLEASE just give me a pill already I hate needles so much — looking for input

RegAffairsDC Mon, Jun 23, 2025 at 6:04 PM 12 replies 1,406 viewsPage 3 of 3
mike_mealprep
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Jun 25, 2025 at 9:06 PM#11
Dr.BariatricHTX said:
Oral semaglutide is absorbed in the stomach with the help of SNAC, which locally raises pH and protects the peptide long enough to cross.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

43 16mia_MS2, LeilaHI, marcus_mpls and 40 others
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PharmacoVig_BOS
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Jun 26, 2025 at 3:32 AM#12

Clinical perspective, offered as context rather than as advice. If two explanations both fit, the useful question is which one predicts something the other does not. That is answerable; arguing about which sounds more plausible is not.

44 17Dr.GutHealth, amsterdam_pete, LondonLisa and 41 others
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Dr.NateNeph
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Jun 26, 2025 at 9:58 AM#13
PedsEndoPhilly said:
The version of this that has an answer is narrower than the version being asked.

Filing a mild objection. Mild because I might be wrong; an objection because nobody has addressed the case that does not fit. The objection nobody has made: this only works if the measurement is doing what we assume it is doing, and that assumption has not been tested here.

45 18SteveThurs, B12Beth, RickReta_CO and 42 others
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lucas_SP_BR
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Jun 26, 2025 at 4:24 PM#14

Adding the numbers, since they settle part of this. Give anything pharmacological four weeks before you judge it, and give anything measured weekly a four-point rolling average before you call it a trend.

That is the short version; the long version is somebody else's post.

Last edited: Jun 26, 2025 at 6:24 PM
46 19KarenAZ_mom, zoe_NC, Dr.ObesityLA and 43 others
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mike_mod
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Jun 26, 2025 at 10:49 PM#15

Moderator note: a couple of off-topic posts removed. Tagging this one for the weekly digest.

47 20PurityPaulOR, MaxMetOK, MounjBrad and 44 others
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