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Evidence-based GLP-1 & peptide discussion since 2023
ForumsOral GLP-1 AgonistsHow far away are we really from an oral option — 12 month update Page 3

How far away are we really from an oral option — 12 month update

HPLC_Greg Wed, Jun 4, 2025 at 7:45 PM 47 replies 2,552 viewsPage 3 of 10
InsuranceTom
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Jun 5, 2025 at 6:41 AM#11
Dr.PeteFamMed said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Agreed, with the usual condition: that holds for the average and this board is a collection of individuals. A population claim and a personal prediction are different things and get quoted interchangeably.

Last edited: Jun 5, 2025 at 11:41 AM
22 20lisa_labSD, adam_van, Dr.SurgeonPGH and 19 others
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MeganSA_TX
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Jun 5, 2025 at 10:39 AM#12
KetoKyle said:
The absorption variability is real, but it partly averages out over weeks — the steady-state trough is less erratic than any single day would suggest.

Genuinely useful, thank you. I had the facts and not the framework. I will report back once I have actually tried it.

Last edited: Jun 5, 2025 at 12:39 PM
23 21julia.endo, JessicaM_2024, TomFromTexas and 20 others
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sophie_paris
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Jun 5, 2025 at 2:36 PM#13
Dr.PeteFamMed said:
Order of operations matters more than any single choice here: establish a baseline, change one thing, wait long enough for it to express itself, then…

Pushing back on Dr.PeteFamMed here. Filing an objection on the n=1 problem. Personal experience is genuine evidence about one person and very weak evidence about anybody else, and this thread keeps promoting the first into the second.

Last edited: Jun 5, 2025 at 7:36 PM
24 22MariaRD, AussieAnna, BethLabQueen and 21 others
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dan_philly
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Jun 5, 2025 at 6:33 PM#14

Adding the numbers, since they settle part of this. The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the same conditions. Nobody wants that answer and it is still the answer.

25 23Dr.CardioMD, EndoResFellow, PharmacoVig_BOS and 22 others
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Admin
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Jun 5, 2025 at 10:30 PM#15

Moderator note: the sourcing question belongs in the vendor section and has been split out. Carry on.

26 24PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 23 others
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