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ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — anyone have experience? Page 6

Orforglipron Phase 3 ATTAIN-1 topline — anyone have experience?

steve_okc Sat, Apr 26, 2025 at 11:16 AM 30 replies 1,800 viewsPage 6 of 6
labquiet_amy
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May 12, 2025 at 10:23 AM#26

A narrower follow-up, since the general answer is now clear:

What did you change at the same time, and can you separate the two now?

Last edited: May 12, 2025 at 12:23 PM
36 9TrialNerd_Beth, HPLC_Greg, LibrarianMeg and 33 others
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Dr.KarenChen
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May 14, 2025 at 5:08 AM#27
hank_denver said:
If you are going to change something, change one thing and give it long enough to express itself.

I read this differently. The confidence in this thread is running ahead of the evidence, and I would rather the uncertainty were stated than smoothed over because it is unsatisfying.

37 10JessicaM_2024, TomFromTexas, mike.trainer_LA and 34 others
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MarkLI_maint
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May 15, 2025 at 11:54 PM#28
hank_denver said:
If you are going to change something, change one thing and give it long enough to express itself.

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Worth separating that from the trial evidence, which this thread keeps folding into the same question. They behave differently and the advice does not transfer.

Last edited: May 16, 2025 at 4:54 AM
38 11HPLC_Greg, LibrarianMeg, bri_stats and 35 others
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nick_SD_fit
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May 17, 2025 at 6:41 PM#29
hank_denver said:
If you are going to change something, change one thing and give it long enough to express itself.

This answered a question I did not know how to ask. Adding it to my notes with a link back to this thread.

39 12PharmacoVig_BOS, SurmountFan_IN, PeptideChemSF and 36 others
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steve_okc
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May 19, 2025 at 1:29 PM#30

OP back with an update, since a thread like this is useless without one.

Update — my curve sits below the published mean and the explanation is that the trial arm had support I do not have. That was reassuring rather than otherwise.

Last edited: May 19, 2025 at 5:29 PM
11 9KetoKyle, CanadaChris, ZaraB_AL and 8 others
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