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ForumsOral GLP-1 AgonistsOrforglipron Phase 3 ATTAIN-1 topline — anyone have experience? Page 5

Orforglipron Phase 3 ATTAIN-1 topline — anyone have experience?

steve_okc Sat, Apr 26, 2025 at 11:16 AM 30 replies 1,800 viewsPage 5 of 6
sarah_TO
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Sep 2024
Toronto, CA
May 3, 2025 at 12:53 PM#21
PeptideChemSF said:
The boring version of this is the one that works, and the boring version is: measure a baseline, change one variable, wait, measure again under the…

Saving this. It is the first explanation that did not require me to already understand it. I will report back once I have actually tried it.

Last edited: May 3, 2025 at 4:53 PM
31 4andrew_nyc, Dr.EndoEP, GraceAZ_72 and 28 others
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Dr.ReproEndo
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May 5, 2025 at 7:33 AM#22

Adding the clinical framing, because it changes how the question reads. Take it one variable at a time. Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent argument can untangle them after the fact.

Last edited: May 5, 2025 at 8:33 AM
32 5andrew_nyc, Dr.EndoEP, GraceAZ_72 and 29 others
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KarenAZ_mom
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Scottsdale, AZ
May 7, 2025 at 2:14 AM#23
Dr.ReproEndo said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

This is my experience too, for whatever a second data point is worth.

33 6bri_stats, pete_manc_UK, anna.melb_AU and 30 others
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tom_AK
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May 8, 2025 at 8:56 PM#24
Dr.ReproEndo said:
Almost every unanswerable question in these threads is unanswerable because three things changed in the same fortnight, and no amount of subsequent…

Adding the part of the answer the thread has not reached. Whatever the answer turns out to be, the method for getting there is the same: state the assumption, do the arithmetic in public, and invite the correction. That is slower than asserting, and it is the only version that survives being wrong.

34 7jennifer_SEA, tyler_CSCS, VanRx_Mike and 31 others
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hank_denver
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Denver, CO
May 10, 2025 at 3:39 PM#25

One concrete data point for the thread. If you are going to change something, change one thing and give it long enough to express itself. Four weeks is the usual minimum for anything pharmacological on this board, and two weeks of data has told you almost nothing.

35 8Dr.DermMIA, fiona_VT, denise_HTX and 32 others
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