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Evidence-based GLP-1 & peptide discussion since 2023
ForumsPublic SquareIs there a ceiling effect for GLP-1-mediated weight loss? — my results so far Page 3

Is there a ceiling effect for GLP-1-mediated weight loss? — my results so far

raj_cambridge Mon, Dec 15, 2025 at 6:20 AM 33 replies 1,411 viewsPage 3 of 7
BenResearch_OR
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Dec 15, 2025 at 9:20 PM#11
NurseAsh_DET said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

True, and it depends on a baseline nobody has stated. Without knowing where someone started, the same number can be an excellent result or a disappointing one.

Last edited: Dec 15, 2025 at 10:20 PM
11 11julia.endo, JessicaM_2024, TomFromTexas and 8 others
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jennifer_SEA
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Dec 16, 2025 at 5:57 AM#12
Dr.PainCLE said:
Propensity score matching studies and the trial evidence: when RCTs aren't available for a specific question, propensity score-matched observational…

Genuinely useful, thank you. I had the facts and not the framework. Adding it to my notes with a link back to this thread.

10 10Dr.ReproEndo, lucas_SP_BR, lisa_labSD and 7 others
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fiona_glasgow
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Dec 16, 2025 at 2:34 PM#13
NurseAsh_DET said:
Forest plot interpretation for the the trial evidence meta-analysis: when reading the pooled estimate, pay attention to: Point estimate (HR/RR/OR) —…

I do not accept the framing. The question has been narrowed to the version that has a tidy answer, and the part that was dropped is the part the OP actually asked about.

9 9KevinCompounds, TirzTom, TrialTracker_MD and 6 others
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PeptideSynthNJ
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Dec 16, 2025 at 11:11 PM#14

One concrete data point for the thread. Say what you would expect to see if you were wrong, before you look. It is a small discipline and it changes what you notice.

8 8MikeKY_noInsulin, Dr.RaviCardio, jennifer_SEA and 5 others
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Admin
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Dec 17, 2025 at 7:48 AM#15

Moderator note: two posts asking for a source have been merged into one. Please search the thread before asking again. No action needed from anybody.

Last edited: Dec 17, 2025 at 11:48 AM
7 7PeptideSynthNJ, Dr.KarenChen, Dr.NateNeph and 4 others
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